ceftriaxone for pneumonia

Ceftriaxone is indicated in the management of the following infections in adults and children including neonates from birth By intravenous injection. Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). Pneumococcal pneumonia caused by organisms that are susceptible or intermediately resistant to penicillin responds to treatment with penicillin, one million units intravenously every 4 hours, ampicillin, 1g every 6 hours, or ceftriaxone, 1g every 24 hours. First choice. Ceftriaxone is a third generation cephalosporin antibiotic that is used in the treatment of bacterial infections caused by susceptible, usually gram-positive organisms. Ceftriaxone 1 to 2 g IV q24h Depends on indication (consult pharmacist) Amoxicillin-Clavulanate 875 mg PO BID Or Cefuroxime 500 mg PO BID Or Cefixime 400 mg PO daily Amoxicillin = 80% Clavulanate = 30 – 98% Cefuroxime = 50% (with food) Cefixime = 50% Gentamicin 6 mg/kg ideal body weight** IV q24h or Ciprofloxacin 750 mg PO BID Klebsiella pneumonia CAP occurs primarily in persons with chronic alcoholism and Staphylococcalaureus may cause CAP in patients with influenza. Twelve studies evaluated ceftriaxone regimens at a dosage of 2 g daily and 12 studies evaluated ceftriaxone at a dosage of 1 g daily. Background. INTRODUCTION Pneumonia may be defined as an inflammation of the parenchyma of the lungs [1]. Side Effects. Although ceftriaxone (CRO) is one of the treatment choices for COP, it is unclear whether 1 or 2 g CRO daily has better efficacy. ICU (No Pseudomonas Risk Factors Present) Ceftriaxone 1 g (2 g if > 80 kg) IV qday PLUS EITHER azithromycin 500 mg PO/IV qday or moxifloxacin* 400 mg PO/IV qday Ceftaroline well-tolerated, comparable to ceftriaxone in community-acquired pneumonia File T. Clin Infect Dis. The role of antibiotics is best established for patients with purulent sputum (usually green) and those who will be admitted to hospital due to severity of their illness 1-3.For patients with community-acquired pneumonia, please see this separate guideline. Recommendations have been made to convert intravenous ceftriaxone, a third generation cephalosporin, to oral cefuroxime, a second-generation cephalosporin. [1, 2] CAP is defined as pneumonia acquired outside a hospital or long-term care facility. In the present report, we investigated the influence of pulmonary infection and IL-10 administration on … Risk factors for Pseudomonas: Previous Pseudomonas sputum colonization or recently hospitalized (last 2. Ceftriaxone . Community acquired PNEUMONIA - Adult (any age) Common pathogens. Background: Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). Streptococcus pneumoniae. Expert opinion: Ceftriaxone dosages of 1 g daily are as safe and effective as other antibiotic regimens for community-acquired pneumonia. However, which of these antibiotics is more effective for treating non-aspiration CAP remains unclear. Albany College of Pharmacy and Health Sciences 106 New Scotland Ave, Albany, NY 12208-3492, USA. Globally, pneumonia is one of the leading causes of morbidity and mortality and accounted for 16% of the estimated 5.9 million deaths among children aged <5 years in 2015. Neutropenia (high-risk) cefotaxime Acute pyelonephritis (severe) cefotaxime Inflammatory and other diseases of prostate (severe) ceftriaxone Inflammatory and other diseases of prostate (severe) ceftriaxone Acute pyelonephritis (severe) Second choice. In adults. These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. To achieve a better therapeutic outcome, Ceftriaxone is indicated in the treatment of the following infections in adults and children including term neonates (from birth): Bacterial Meningitis. Ceftriaxone therapy was appropriate in 30 (27.5%) cases and 68 (62.4%) cases were inappropriate in any of the four parameters of assessment used. Patients … Aspiration pneumonia is the only form of CAP caused by multiple pathogens (eg, aerobic/anaerobic oral organisms). Doxycycline* 100 mg PO/IV q12h. Description: Ceftriaxone is a 3rd generation cephalosporin antibiotic. community-acquired pneumonia, severe bacterial [>3 mo] Dose: 50-100 mg/kg/day IM/IV divided q12-24h x10 days; Max: 2 g/day; Info: may switch to PO regimen when possible to complete course UTI [2 mo-2 yo] Dose: 75 mg/kg/dose IM/IV q24h x7-14 days; Info: duration varies w/ infection type, severity *infections, gonococcal 125mg bd*. Inappropriate use of ceftriaxone was found to be high in the hospital. Efficacy of Ceftriaxone 1 g daily Versus 2 g daily for The Treatment of Community-Acquired Pneumonia: A Systematic Review with Meta-Analysis Expert Rev Anti Infect Ther. 2019 Jul;17(7):501-510.doi: 10.1080/14787210.2019.1627872. Amoxycillin 875mg with clavulanic acid. Alexandra Carides. Uses: For the treatment of serious miscellaneous infections when due to susceptible organisms; may include: -Bacterial septicemia due to S aureus, S pneumoniae, E coli, H influenzae, or K pneumoniae. Keywords: Community Acquired Pneumonia; Ceftriaxone; Levofloxacin 1. Community-acquired pneumonia (CAP) is one the most common infectious diseases addressed by clinicians. Observational Study. Community acquired pneumonia. Hospital acquired pneumonia. Ceftriaxone 1 g IV daily 1,5+Azithromycin 500 mg PO x 1, then 250 mg PO daily x 4 more days. If the child's condition does not improve after 48 hours with ceftriaxone + cloxacillin, consider tuberculosis. These guidelines are being updated and will be availalbe Spring 2018. Ceftriaxone. DB01212. Ceftriaxone 1gm IV Q24H plus Azithromycin 500mg PO/IV Q24H Consider addition of Vancomycin and ID consult if risk factors for MRSA pneumonia: necrosis/cavitation, post-influenza pneumonia or other clinical suspicion for S. aureus pneumonia No change Levofloxacin 750mg PO/IV Q24H* See recommendations regarding suspected MRSA in first box Health care-associated / hospital-acquired pneumonia … Hospitalized patient: Azithromycin 500mg IV once daily PLUS Ceftriaxone 1 gram q24h (OR) Azithromycin 500mg IV once daily PLUS. Common pathogens. Find patient medical information for ceftriaxone intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Levofloxacin should not be used routinely as step-down therapy for pneumococcal pneumonia if the organism is susceptible to beta-lactams. 1. Ceftriaxone is contraindicated in patients with cephalosporin hypersensitivity or cephamycin hypersensitivity. Despite the availability of potent new … Twenty-four articles fulfilled the inclusion criteria. Ease of administration favors the use of ceftriaxone. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Community-acquired pneumonia, COPD: Most commonly 500 mg IV x1, then 250 mg IV daily x4 days. Of the different types, com- munity acquired pneumonia (CAP) is the most common and important from public health point of view. Abstract Background Community-onset pneumonia (COP) is a combined concept of community acquired pneumonia and the previous classification of healthcare-associated pneumonia. Preliminary study suggests that a regimen of 500 mg a day may be effective in selected patients with simple pneumonias caused by sensitive pathogens. Download Full PDF Package . by Thomas P. Lodise. However, its use to treat infections caused by methicillin-susceptible Staphylococcus aureus (MSSA) is controversial given limited evidence of its clinical efficacy. Patients hospitalized with community-acquired pneumonia were randomized, for 5 to 7 days, to either ceftaroline 600 mg twice daily (n = 381) or to ceftriaxone … One of the following agents with MRSA activity: Clindamycin 10mg/kg/dose IV q8h (max 900mg/dose) for clinically stable patients. Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Pharmacology & Pharmacy, ceftriaxone, critically ill, pharmacokinetic, community-acquired pneumonia, severe CAP, target attainment, protein binding, unbound concentration, COMMUNITY-ACQUIRED PNEUMONIA, PLASMA-PROTEIN BINDING, INTENSIVE-CARE-UNIT, BETA-LACTAM ANTIBIOTICS, PHARMACOKINETICS, … Amikacin. Community-acquired pneumonia (CAP) is a major reason for hospital admission [1,2,3].Five to forty percent of the patients hospitalized with a diagnosis of CAP require admission to the intensive care unit (ICU), which is then commonly defined as severe CAP [].Ceftriaxone is a first-line antimicrobial often prescribed for the empirical treatment of severe CAP. PubMed ID. 87% of those users who reviewed Ceftriaxone reported a positive effect, while 7% reported a negative effect. This study was a prospective, single-center, open-label, quasi-randomized controlled trial. Ceftriaxone has a longer half-life and therefore needs to be given only once daily. Three studies used ceftriaxone as an adjunctive therapy for the treatment of MSSA or did not describe MSSA infections [13,14,15]. The calcium salt of ceftriaxone forms a precipitate in the gall bladder which may rarely cause symptoms but these usually resolve when the antibiotic is stopped. Morbid obesity or severe illness: may consider 500 mg IV daily. If tuberculosis is unlikely, continue with ceftriaxone + cloxacillin and add azithromycin (see Atypical pneumonia). azithromycin or doxycycline* Ceftriaxone 1 gram (2 grams if > 80 kg) IV qday . AbstractBACKGROUND:Limited data exist on the effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community‐acquired pneumonia (CAP).METHODS:We performed a retrospective cohort study of all adults hospitalized for pneumonia between January 1999 and July 2001 at an academic medical center. The presence of pneumonia will alter the antibiotic recommendations. Multicenter Study. 1 In 2010, there were 120 million episodes of pneumonia in children younger than 5 years, and 14 million pneumonia cases progressed to severe and life-threatening conditions requiring urgent hospital care. Indications include serious infections such as septicaemia, pneumonia, and meningitis. 2010;51:1395-1405. Common clinical symptoms of CAP include cough, fever, chills, fatigue, dyspnea, rigors, and pleuritic chest pain. Download PDF. Published pharmacokinetic (PK) models for levofloxacin and ceftriaxone… Early antibiotics for community-acquired pneumonia (CAP) can improve outcomes, but diagnostic uncertainty makes timely intervention difficult. Amikacin. Alexandra Carides. Ceftriaxone has an average rating of 8.9 out of 10 from a total of 15 ratings for the treatment of Pneumonia. Shah and Stille , in reporting their randomized trial comparing cefotaxime versus ceftriaxone for the treatment of nosocomial pneumonia, actually described the frequency of symptoms at study entry. Pneumonia, Community-Acquired (>3 Months) 50-100mg/kg/day IM/IV divided q12-24h x 10 days; First Dose: Max: 2g/day; Info: May switch to PO when possible to complete course ; Special Populations. Rocephin comes in the form of a solution and is given either as a shot or through an intravenous line (IV). Pneumonia is a major cause of sickness and death in the Black American community. PLUS . This retrospective analysis compares the probability of target attainment (PTA) for ceftriaxone, levofloxacin and ceftaroline fosamil against Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae in a representative patient population with moderate-to-severe community-acquired pneumonia (CAP). Used very commonly together. Kenneth LaPensee. Ceftriaxone causes bacteriolysis of pneumococcus, releasing inflammatory cell wall products that exacerbate meningeal inflammation. can antibiotics S.T.O.P. Acute complicated urinary tract infection (including pyelonephritis) in adults. No co-morbidities: Azithromycin 500 mg x1, then 250 mg once daily OR azithromycin 2 gm (XR) x 1 dose (OR) Clarithromycin 500mg orally twice daily or 1gram (XR) orally once daily x 7 days (OR) Doxycycline 100mg orally twice daily. The principal problem is that at the time treatment is begun, the etiology is likely not to be known. If a Gram stain of sputum at admission shows pneumococci, ceftriaxone is the preferred drug, unless the patient is extremely ill, in which case vancomycin should be added until the susceptibility of the infecting organism is known. clinical stability. POCUS perfomed by experienced operators is more accurate than chest x-ray for community acquired pneumonia, but is limited by the time it takes to perform. Pub Type(s) Journal Article. Community acquired pneumonia (CAP) treatment . One gram once daily of ceftriaxone is as effective as 2 gm for the common causative organisms of community-acquired and nosocomial pneumonias. Fever was present in 82% of their patients, and chest pain was present in 46%, cough with or without sputum present in 85%, dyspnea in 72%, pulmonary consolidation in 64%, rales in 85% and a … Meningitis caused by Haemophilus influenzae, Neisseria meningitidis or Streptococcus pneumoniae. We explored whether early (first 24 hours) use of ceftriaxone and azithromycin identified CAP patients and … Ceftriaxone–levofloxacin combination is the most frequently used antimicrobial for the treatment of Streptococcus intermedius pleuropulmonary infection; drainage of pleural effusion and other surgical procedures such as pleurectomy, thoracotomy, decortication, and debridement are recommended along with antibiotic therapy for treatment. Two studies were in vitro models [4,16], one lacked a comparator and one study did not use ceftriaxone . One gram once daily of ceftriaxone is as effective as 2 gm for the common causative organisms of community-acquired and nosocomial pneumonias. It should not be used alone against L. pneumophila, the TWAR pneumoniae, and possibly anaerobic pathogens. Intravenous to Oral Switch Guideline for Adults Patient. Legionella pneumonia: 500 mg IV daily for 5-10 days. Pneumonia: Community acquired. In contrast, hospital-acquired pneumonia (HAP) is seen in patients who have recently visited a hospital or who live in long-term care facilities. Two studies [19,20] assessed a population that presented with pneumonia not demonstrated to be due to MSSA. Guidance on Use of the Pneumonia Panel for Respiratory Infections Although the number of pathogens that cause pneumonia is lengthy, establishing the microbiologic etiology of pneumonia is inherently difficult. An acute exacerbation of COPD (AECOPD) is defined by an acute worsening of cough or dyspnea or increased sputum production. Ertapenem versus ceftriaxone for the treatment of community-acquired pneumonia in adults: combined analysis of two multicentre randomized, double-blind studies. Initial outpatient therapy should incl… It should not be used alone against L. pneumophila, the TWAR pneumoniae, and possibly anaerobic pathogens. Early antibiotics for community-acquired pneumonia (CAP) can improve outcomes, but diagnostic uncertainty makes timely intervention difficult. see COPD order set; Pneumonia: AECOPD may be associated with pneumonia. A Study Evaluating the Efficacy, Safety, and Tolerability of Ertapenem versus Ceftriaxone for the Treatment of Community‐Acquired Pneumonia in Adults … (outpatient therapy) Adult patient. 1–2 g once daily, 2 g dose to be used for hospital-acquired pneumonia and severe cases. It is evident from a reviewing the recommendations of several medical-specialty professional societies (table 1) that combination therapy with a β-lactam plus a macrolide or doxycycline or monotherapy with a “respiratory quinolone” (i.e., a 31736321. Differentiating viral and bacterial pneumonia. In the USA, the first case of penicillin-non-susceptible S. pneumoniae meningitis was reported in 1974.1 Since then, cases of meningitis caused by S. pneumoniae with reduced penicillin susceptibility have been increasingly reported. For Child 9–11 years (body-weight 50 kg and above) 1–2 g once daily, 2 g dose to be used for hospital-acquired pneumonia and severe cases. "im currently taking trimethoprim 200mg twice daily but will be having ceftriaxone and azithromycin treatment soon. Ceftriaxone and cefoperazone monotherapy was compared in a multicentered, randomized, nonblinded, prospective study of patients with nosocomial pneumonia. Streptococcus pneumoniae: IV: penicillin G OR ceftriaxone OR azithromycin; PO: amoxicillin OR cefpodoxime OR azithromycin. Ultrasound examination may offer an ideal alternative … Pseudomonas aeruginosa is a cause of CAP in patients with bronchiectasis or cystic fibrosis. Introduction. Ceftriaxone has been particularly recommended for …. A 2014 meta-analysis concluded that, in the hands of experienced operators, ultrasound examination has a sensitivity and specificity as high as 94% and 96%, respectively. Hasegawa, Shinya, et al. IDSA guidelines from 2007 do not give specific dose recommendations for ceftriaxone for the treatment of CAP. any possible negative interaction?" Ceftriaxone is also used to treat pelvic inflammatory disease, bacterial septicemia, bone … Community-acquired pneumonia (CAP) refers to pneumonia (any of several lung diseases) contracted by a person outside of the healthcare system. The study demonstrates an association between the use of a specific antibiotic for pneumonia treatment and post pneumonia mortality in patients who developed C. difficile infection.” Acute otitis media. Community acquired pneumonia (CAP) can be diagnosed clinically when there are signs of a lower respiratory tract infection and wheezing syndromes have been ruled out “The corollary is that ceftriaxone should be shunned in pneumonia treatment. Read our disclaimer for details. To evaluate if treatment with ceftriaxone and a macrolide, improved patient outcome when compared with monotherapy with ceftriaxone, in hospitalized patients with human immunodeficiency virus/acquired immunodeficient syndrome (HIV/AIDS) with community-acquired pneumonia (CAP). ACCESS group. It is a major health problem in the United States and is an important cause of mortality and morbidity worldwide. Ceftriaxone. For the diagnosis, refer to the guide Tuberculosis, MSF. The structural similarity between ceftriaxone and penicillin means that cross-reactivity can occur. 1g-2g daily. Ceftriaxone has the longest serum half-life of this group (6.4 hours) and can be administered once or twice a day. Azithromycin 500 mg PO/IV qday . It binds to 1 or more penicillin-binding proteins (PBPs) inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, leading to bacterial cell lysis and death. eng. Alternative: 500 mg IV daily for three days (long half-life in tissues so will have biologic effect >>3 days). … Thirty-nine of the children had been successfully treated with various oral antibiotics prior to admission. Community-acquired pneumonia (CAP) is defined as pneumonia not acquired in a hospital or a long-term care facility. …hours), allowing dosing every six hours. Complicated urinary tract infections (including pyelonephritis) Infections of bones and joints . Duration of therapy: 5 days is recommended 4,5; OTHER CONSIDERATIONS: Systemic corticosteroid & Bronchodilator therapy. Keyword : Ceftriaxone, Pneumonia Komunitas, Rawat Inap ABSTRAK (1)Hidajah Rachmawati, (2)Didik Hasmono Latar Belakang: Pneumonia merupakan penyakit menular yang menyebabkan rawat inap dan kematian pada orang dewasa didunia dan 5 kali lebih sering menyerang di Negara berkembang. Penicillins can cause a variety of hypersensitivity reactions ranging from mild rash to fatal anaphylaxis. OUTPATIENT. Maximum dose: 2 g/day. A post by Jay Harold states that over 5500 Black Americans died of Pneumonia and the Influenza in 2015. Initial evaluation should determine the need for hospitalization versus outpatient management using validated mortality or severity prediction scores. DrugBank Accession Number. ›. * Their analysis showed that the direct cost per … Gail Woods. Amoxicillin is also used to treat gonorrhea. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Objectives: Anti-inflammatory therapy with interleukin-10 (IL-10) was previously reported to reduce pulmonary inflammation and to prevent septicaemia in murine pneumococcal pneumonia treated with ceftriaxone. Ceftriaxone should be used cautiously in patients with hypersensitivity to penicillin. For Child 12–17 years. Ceftriaxone has an invitro activity against gram positive and gram negative aerobic and anaerobic bacteria. Citation. Title:Levofloxacin Versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients VOLUME: 13 ISSUE: 3 Author(s):Mehran Izadi, Banafsheh Dadsetan, Zeinab Najafi, Sirous Jafari, Elham Mazaheri, Omid Dadras, Hajar Heidari, SeyedAhmad SeyedAlinaghi* and Fabricio Voltarelli The S. anginosus group (SAG) – also known … Selected diagnostic laboratory testing, such as sputum and blood cultures, is indicated for inpatients with severe illness but is rarely useful for outpatients. Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia (CAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In rabbits, steroid pre-treatment blocks this surge in inflammation (Lutsar 2003). 1–2 g once daily, 2 g dose to be used for hospital-acquired pneumonia and severe cases. A short summary of this paper. Ceftriaxone 50mg/kg/dose IV q24h (max 2g/dose) AND. The odds-ratio of clinical cure in the modified intention-to-treatment patients administered either ceftriaxone … This paper. Answered by Dr. Bahman Omrani: Interactions are : Rare. Staphylococcus aureus. Similarly, recent pharmacodynamic analyses suggest shortcomings of 1 g q24h against the bulk of the MSSA. Gail Woods. At IDWeek 2012, researchers presented that the addition of azithromycin to ceftriaxone therapy for children hospitalized with community-acquired pneumonia (CAP) … Journal of Antimicrobial Chemotherapy, 2004. User Reviews for Ceftriaxone to treat Pneumonia. We compared the effectiveness of 1 g with 2 g of CRO for COP treatment. We explored whether early (first 24 hours) use of ceftriaxone and azithromycin identified CAP patients and what downstream antibiotic decisions followed this treatment. Antibiotic. Ceftriaxone is an empirical antibiotic commonly used to treat pneumonia. Streptococcus pneumoniae is one of the most frequent causative agents of community-acquired infections, including bacteraemia, pneumonia and meningitis. Cefuroxime (Ceftin) 500 mg PO Q12h (7 days total) and/or. Consequently, it not surprising that ceftriaxone, when given in a single daily injection, was effective for pediatric patients presumed to have a bacterial pneumonia. Original studies of ceftriaxone in the 1980s and 1990s demonstrated 1 gram doses were as good as 2 gram doses for the treatment of moderate to severe … Amoxicillin and ceftriaxone are antibiotics used to treat bacterial infections of the middle ear, tonsils, throat, respiratory tract, urinary tract, and skin. Clarithromycin WHO Antibiotics Portal. Ceftriaxone, sold under the brand name Rocephin, is an antibiotic used for the treatment of a number of bacterial infections. Language. Ceftriaxone, a broad spectrum third-generation cephalosporin with a half-life of six to eight hours, was evaluated prospectively in 147 children with severe community-acquired bacterial pneumonia during the period 11/15/88-5/15/89. Available only by prescription, Rocephin ® ( ceftriaxone) is a medication approved to treat a wide variety of bacterial infections, including pneumonia. Research Support, Non-U.S. Gov't. Overview. Rocephin for Pneumonia. Pneumonia adalah suatu peradangan paru yang disebabkan oleh mikroorganisme. Indications. 3,‡ 1. Ceftriaxone is an empirical antibiotic commonly used to treat pneumonia. Ertapenem 1 gram q24h (OR) Monotherapy: Levofloxacin 750 mg IV/PO once daily (OR) Moxifloxacin 400mg IV qd. Community-acquired pneumonia is diagnosed by clinical features (e.g., cough, fever, pleuritic chest pain) and by lung imaging, usually an infiltrate seen on chest radiography. necrotizing pneumonia, or recently hospitalized (last 90 days) and treated with broad spectrum antibiotics for at least 5 days (both antibiotic and hospital stay required). Notes: – For malnourished children, refer to specific protocol. Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. There are limited cues for differentiating bacterial and viral pneumonia. 2,† and . 1 month or older: 50 to 75 mg/kg/day IV or IM in divided doses every 12 hours. Ceftriaxone 2gm IV Q12 hours + Vancomycin (20-25mg/kg load plus Rx to Dose) + Ampicillin 2gm IV Q4 hours Neutropenic Fever5 S. epidermidis K. pneumonia P. aeruginosa S. +/aureus E. coli Zosyn 3.375 gm IV Q8 hours +/- 3 Vancomycin (20-25mg/kg load plus Rx to Dose)-Levofloxacin 750 mg IV q24h Continue until neutropenia subsides *If oral route not an option, consider ceftriaxone 1 g IV daily. Community-acquired pneumonia, Hospital-acquired pneumonia, Intra-abdominal infections, Complicated urinary-tract infections, ... Ceftriaxone is used for Lyme disease affecting the central nervous system in children with body-weight 50 kg and over and in children aged 12 years and over, but the dose is not licensed for this indication. Hospital Admission Patterns in Adult Patients with Community-Acquired Pneumonia Who Received Ceftriaxone and a Macrolide by Disease Severity across United States Hospitals . These antibiotics were equally effective, with an overall successful treatment rate of 48 (80%) of 60 for the cefoperazone-treated patients and 35 (70%) of 50 for the ceftriaxone-treated patients.

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