rilpivirine hydrochloride

Tenofovir Disoproxil Fumarate: Tenofovir DF is a fumaric acid salt of the bis-isopropoxycarbonyloxymethyl ester derivative of tenofovir. Rilpivirine hydrochloride has the following structural formula:Rilpivirine hydrochloride is a white to almost white powder. Rilpivirine is an aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. The rilpivirine hydrochloride monohydrate may preferably be formulated into tablets, capsules, suspensions, dispersions, injectables or other pharmaceutical forms. significant decreases in rilpivirine plasma concentrations may occur, which may result in loss of virologic response and possible resistance and cross-resistance. 21/09/20. Do not take Odefsey with other HIV medicines. The purpose of this study is to assess the safety and effectiveness of rilpivirine hydrochloride in combination with other anti-retroviral (ARV) medications for the treatment of ARV-naive (patients who have not been exposed to ARV) Filipino patients with human immunodeficiency virus type 1 (HIV-1) infection. Details. Rilpivirine hydrochloride is a white to almost white powder. Dolutegravir sodium, Rilpivirine Hydrochloride. The applicant requested the active substance rilpivirine (hydrochloride) contained in the above medicinal product to be considered as a new active substance in itself. -. Rilpivirine Hydrochloride is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: Hiv infection. Rilpivirine absorption is sensitive to gastric pH; proton-pump inhibitors should not be co-administered, and H2 receptor antagonists and antacids require spacing of doses. Rilpivirine has a half-life of 50 hours and is metabolized by CYP3A4-mediated hepatic oxidation; no inhibition or induction of cytochrome P-450 isoenzymes has been reported. rilpivirine hydrochloride. It blocks the activity of reverse transcriptase, an enzyme produced by HIV-1 that allows it to make more viruses in the cells it has infected. NDC Product Information. Each EDURANT tablet also contains the inactive ingredients croscarmellose sodium, magnesium stearate, lactose monohydrate, povidone K30, polysorbate 20 and silicified microcrystalline cellulose. Supplier Information. Edurant is an antiviral medicine. 30/07/20. Both the Rilpivirine hydrochloride ( E ‐isomer) and Impurity‐A ( Z ‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Each tablet contains: 50 mg of dolutegravir (equivalent to 52.6 mg dolutegravir sodium) and 25 mg of rilpivirine (equivalent to 27.5 mg rilpivirine hydrochloride). Rilpivirine, sold under the brand names Edurant and Rekambys, is a medication, developed by Tibotec, used for the treatment of HIV/AIDS. Qualitative and quantitative composition. Rilpivirine hydrochloride did show the presence of imp-2 imp-4 at minor concentrations, and also contained 0.02% of unknown. Report your Use ». The method was validated in terms of specificity, Each tablet contains 200 mg of FTC, 27.5 mg of rilpivirine hydrochloride (equivalent to 25 mg of RPV), and 300 mg of TDF (equivalent to 245 mg of tenofovir disoproxil) as active ingredients. Rilpivirine hydrochloride is a white to almost white powder. Rilpivirine is associated with a low rate of transient serum aminotransferase elevations during therapy and has been implicated in rare cases of clinically apparent acute liver injury. "Emtricitabine mixture with rilpivirine hydrochloride and tenofovir disoproxil fumarate". S. Venkatesan, N. Kannappan, Sai Sandeep Mannemala, " Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms ", International Scholarly Research Notices, vol. 30/07/20. Each tablet contains: 200 mg emtricitabine (brand name: Emtriva) 25 mg rilpivirine (brand name: Edurant) 25 mg tenofovir alafenamide. Emtricitabine, Rilpivirine Hydrochloride, Tenofovir disoproxil fumarate. Gilead Sciences Ltd. Juluca 50 mg/25 mg film-coated tablets. Last updated on Sep 24, 2020. Odefsey with NDC 61958-2101 is a a human prescription drug product labeled by Gilead Sciences, Inc.. The product's dosage form is tablet and is administered via oral form. Odefsey comes in tablet form. The mobile phase used was ammonium acetate buffer (pH 4) and acetonitrile in isocratic mode (Reddiah et al., 2012). rilpivirine hydrochloride, which is equivalent to 25 mg of rilpivirine.The chemical name for rilpivirine hydrochloride is 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]2-pyrimidinyl]amino]benzonitrile monohydrochloride. Gilead Sciences Ltd. Juluca 50 mg/25 mg film-coated tablets. ViiV Healthcare UK Ltd. Odefsey 200 mg/25 mg/25 mg film-coated tablets. 1 It is a diarylpyrimidine derivative. Rilpivirine hydrochloride is a diarylpyrimidine derivative that acts as a reverse transcriptase inhibitor with antiviral activity against HIV-1. Chemsrc provides rilpivirine hydrochloride(CAS#:700361-47-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Rilpivirine hydrochloride is practically insoluble in water over a wide pH range. rilpivirine hcl. Each fixed-combination tablet contains 50 mg of dolutegravir and 25 mg of rilpivirine. 21/09/20. ViiV Healthcare UK Ltd. Odefsey 200 mg/25 mg/25 mg film-coated tablets. [5] [6] It is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency , longer half-life and reduced side-effect profile compared with older NNRTIs such as efavirenz . Adults Treatment of HIV-1 Infection Antiretroviral-experienced Adults Oral Drug Information Portal. EDURANT 25 mg film-coated tablets. Rilpivirine hydrochloride did show the presence of imp-2 imp-4 at minor concentrations, and also contained 0.02% of unknown. RILPIVIRINE HYDROCHLORIDE 212WAX8KDD Overview Structure Names 18: Classification 3: Identifiers 10: Relationships 1: Active Moiety 1: Notes 3: Audit Info References 28: Moieties 2: Substance Class: Chemical Record UNII: 212WAX8KDD. Take Odefsey one time each day with a meal. This lowers your chance of getting HIV complications (such as new … Used for treatment of HIV. Rilpivirine, 4-{[4-({4-[(E)-2-cyanovinyl]-2, 6-dimethylphenyl} amino) pyrimidin-2-yl] amino} benzonitrile is a pharmaceutical drug used for the treatment of HIV infection. Definition. Rilpivirine hydrochloride, 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile monohydrochloride, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) and indicated for the treatment of HIV-1 infection in treatment-naïve adult patients in combination with other antiretroviral agents. Rilpivirine is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. CONTRAINDICATIONS. Its molecular formula is C22H18N6 • HCl and its molecular weight is 402.88. Rilpivirine hydrochloride is a white to almost white powder. Rilpivirine. Available as fixed-combination tablets containing dolutegravir sodium and rilpivirine hydrochloride; dosages expressed in terms of dolutegravir and rilpivirine, respectively. It has a role as a prodrug, a HIV-1 reverse transcriptase inhibitor and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. 2. The tablets include the following inactive ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polysorbate 20, povidone, pregelatinized starch. Each tablet contains 27.5 mg of rilpivirine hydrochloride, which is equivalent to 25 mg of rilpivirine. Name Rilpivirine hydrochloride Drug Entry Rilpivirine. Edurant. Standard addition and recovery experiments are conducted to determine the accuracy of the related substance method for the quantification of all six impurities (imp-1, imp-2, imp-3, imp-4, imp-5 and imp-6) in the drug substance. The generic name of Odefsey is emtricitabine, rilpivirine hydrochloride, and tenofovir alafenamide. U.S. National Library of Medicine. Coadministration with dofetilide. The contents of rilpivirine, rilpivirine hydrochloride, rilpivirine hydrochloride monohydrate and the impurities are determined by High performance liquid chromatography (HPLC). Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Used for treatment of HIV. Structure, properties, spectra, suppliers and links for: Rilpivirine Hydrochloride, 700361-47-3. -. Rilpivirine, also known as TMC278, is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz. Name of the medicinal product. CHEBI:68602. Previous hypersensitivity reaction to dolutegravir or rilpivirine. Rilpivirine hydrochloride is a hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid.Used for treatment of HIV. (4) -----WARNINGS AND PRECAUTIONS -----­ • Caution should be given to prescribing EDURANT with drugs that may reduce the exposure of rilpivirine. Labeler Name: Gilead Sciences, Inc. Rilpivirine Hydrochloride, trade name Edurant is a pharmaceutical developed by Tibotec, for the treatment of HIV infection. Take Odefsey according to your health care provider’s instructions. Synonym N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. Rilpivirine Hydrochloride may also be used for purposes not listed here. This entity has been manually annotated by the ChEBI Team. This page was last edited on 3 May 2021, at 21:40 (UTC). Rilpivirine was approved for use in the United States in May 2011. Dolutegravir sodium, Rilpivirine Hydrochloride. EP2755959A1 EP12831918.3A EP12831918A EP2755959A1 EP 2755959 A1 EP2755959 A1 EP 2755959A1 EP 12831918 A EP12831918 A EP 12831918A EP 2755959 A1 EP2755959 A1 EP 2755959A1 Authority EP European Patent Office Prior art keywords rilpivirine solvent solution hydrochloride mixture Prior art date 2011-09-16 Legal status (The legal status is an assumption and … The applicant received Scientific Advice from the CHMP on 19 July 2007, 24 April 2008 and 22 October Articles of rilpivirine hydrochloride … Nuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Excipient with known effect. ChEBI ID. Disoproxil Fumarate and 2.5-12.5µg/mL for Rilpivirine Hydrochloride with correlation coefficients in the range of 0.997-0.999. Emtricitabine, Rilpivirine Hydrochloride, Tenofovir disoproxil fumarate. Rilpivirine hydrochloride during its in vitro dissolution study. Each film-coated tablet contains rilpivirine hydrochloride equivalent to 25 mg rilpivirine. Each film-coated tablet contains 56 mg lactose monohydrate. Class: HIV Nonnucleoside Reverse Transcriptase Inhibitors Chemical Name: Benzonitrile, 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-,hydrochloride Molecular Formula: C 22 H 18 N 6 •HCl CAS Number: 700361-47-3 Brands: Edurant Medically reviewed by Drugs.com. It has a role as a HIV-1 reverse transcriptase inhibitor and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. 25 mg white to off-white, film-coated, round, biconvex, tablet of 6.4 mm, debossed with “TMC” on one side and “25” on the other side. Scientific Advice . (Fathima et al., 2018) had reported a reverse phase-high-performance LC method for the quantification of Rilpivirine hydrochloride among 4 CONTRAINDICATIONS The active substance in Edurant, rilpivirine, is a non-nucleoside reverse-transcriptase inhibitor (NNRTI). Stars. Emtricitabine; Rilpivirine Hydrochloride; Tenofovir Alafenamide Fumarate Complete regimen for the treatment of HIV-I infection in atients 12 ears of a e and older Chronic (classified as 1-10 years of use for purposes of setting limits on mutagenic im Illities er ICH M7 I tablet per day None Rilpivirine rilpivirine solvent hydrochloride monohydrate solution rilpivirine hydrochloride Prior art date 2011-09-16 Legal status (The legal status is an assumption and is not a legal conclusion. Rilpivirine hydrochloride is practically insoluble in water over a wide pH range. Rilpivirine hydrochloride is practically insoluble in water over a wide pH range.Each EDURANT tablet also contains the inactive ingredients croscarmellose sodium, lactose monohydrate, magnesium stearate, polysorbate 20, povidone K30 and silicified microcrystalline … Rilpivirine hydrochloride is practically insoluble in water over a wide pH range. Each EDURANT tablet also contains the inactive ingredients croscarmellose sodium, lactose monohydrate, magnesium stearate, polysorbate 20, povidone K30 and silicified microcrystalline cellulose. Rilpivirine hydrochloride was approved by the U.S. Food and Drug Administration (FDA) on May 20, 2011, then approved by European Medicine Agency (EMA) on Nov 28, 2011, and approved by Pharmaceuticals and Medicals Devices Agency of Japan (PMDA) on May 18, 2012, following by China Food and Drug Administration (CFDA) on Dec 31, 2012.

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