pathophysiology of dengue fever pdf

Dengue infection is caused by any of four dengue virus serotypes. van Mild dengue fever causes a high fever and flu-like symptoms. Dengue and Dengue Hemorrhagic Fever. These viruses are transmitted to us through bites from mosquitoes, particularly from the species Aeded aegypti and the related species Aedes albopictus. Add to cart. Chapters. Dengue fever is an arboviral infection spread by the Aedes mosquito with a wide spectrum of presentations encompassing simple flu-like illness to hemorrhagic manifestations. Dengue Hemorrhagic Fever & Dengue Shock Syndrome; Dengue Hemorrhagic Fever (DHF) Fever, or history of acute fever, lasting 2–7 days, occasionally biphasic PLUS Hemorrhagic tendencies, evidenced by at least one of the following: A positive tourniquet test † Petechiae, ecchymoses, or purpura Pathophysiology of Dengue Encephalitis - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. Dengue Fever Presentation . SUMMARYMuch remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans. J Infect Dis 2015; 212:711. B, Clinical course and labo-ratory diagnosis of dengue fever. World Health Organization, Regional Office for South-East Asia. Primary health care pdf, 33kb; Annex 1. pathogenesis and pathophysiology of dengue fever and dengue … RT-PCR using consensus primers and four type-specific downstream primers based on the NS3 gene can discriminate all four virus serotypes. Abstract. They are RNA viruses that belong to the Flavivirus genus/Flaviviridae family, which also includes the yellow fever virus, West Nile virus, Japanese encephalitis virus, Zika virus, and the St Louis encephalitis virus. Persons who develop severe dengue infections are more likely to become hospitalized or die. PDF. PowerPoint is the world's most popular presentation software which can let you create professional Dengue Fever powerpoint presentation easily and in no time. Dengue fever is a disease transmitted by mosquitoes to the people and is commonly caused by flavivirus. T/C Dengue Hemorrhagic Fever/ Pleural Effusion, T/C Liver Pathology. Young adults and elderly participants had a low perception of susceptibility to DF. Dengue fever, caused by infection with dengue virus, is not a new disease, but recently because of its serious emerging health threats, coupled with possible dire consequences including death, it has aroused considerable medical and public health concerns worldwide. patho-physiology XI. Sophie Yacoub, Phung Khanh Lam, Trieu Trung Huynh, Hong Hanh Nguyen Ho, Hoai Tam Dong Thi, Nguyen Thu Van, Le Thi Lien, Quyen Nguyen Than Ha, Duyen Huynh Thi Le, Juthathip Mongkolspaya, Abigail Culshaw, Tsin Wen Yeo, Heiman Wertheim, Cameron Simmons, Gavin Screaton, Bridget Wills, Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study… The pathophysiology of dengue hemorrhagic fever … Pathophysiology. The severe form of dengue fever, also called dengue hemorrhagic fever, can cause serious bleeding, a sudden drop in blood pressure (shock) and death. Dengue Fever is a mosquito-borne (Aedes aegytpi and rarely the Aedes albopictus species) disease with no apparent animal reservoir. Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study. The pathophysiology of dengue especially dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) were rarely known; as a result, it was seen as deadly by some but was also perceived as easily curable by others without a basis of understanding. This helps you give your presentation on Dengue Fever in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.. … The dengue virus is transmitted by mosquitoes. 4.3 Pathogenesis and pathophysiology ..... 22 4.4 Clinical laboratory findings of DHF ... dengue fever, DHF and DSS were also incorporated in these revised guidelines. Clinically apparent dengue (DEN) virus infection is associated with a range of syndromes. Dengue virus infection is a major cause of morbidity, mortality, and economic hardship in the tropics and subtropics [1, 2]. 38, No. Dengue virus (DENV), a member of the Flaviviridae family, causes the most widespread mosquito-borne viral infection in humans around the world today. Typhoid Fever Pathophysiology amp; Schematic Diagram • Severe dengue: dengue with any or more of the following scenarios: o Severe plasma leakage evidenced by hypovolemic shock and/or extravascular fluid accumulation with respiratory distress possibly with a abnormally high hematocrit value. What is Dengue? Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. This condition is called Dengue Hemorrhagic Fever (DHF). Molecular strategies are leading to more rapid techniques for detecting dengue viral RNA, antigens and antibodies. Virology and Laboratory Diagnosis 4-6 3. The signs are: cool blotchy skin which is also clammy; circumoral cyanosis may be present; the pulse rate increases and is weak; blood pressure is low and falls; the patient is lethargic initially and becomes restless as … Acute pancreatitis as a complication of dengue fever. Clinical Microbiology Reviews, 1998:480-96 f Pathophysiology changes • Water and electrolyte shift • Blood pressure • Platelets • Coagulation factors • Complement consumption • Vascular permeability mediators • Immune complexes • Leucocytes responses Scott B. Halstead. Dengue haemorrhagic fever: questions of pathogenesis Mary Jane Cardosa The year under review has seen a remarkable proliferation of papers on dengue. SUMMARY. Dengue can affect anyone but tends to be more severe in people with compromised immune systems. Download Full PDF Package. Dengue infection may cause fever… 1. Dengue - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Countries or territories in which dengue or dengue haemorrhagic fever is known to occur, by WHO Region, 1975-1996 pdf, 26kb; Annex 2. Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection.VHFs may be caused by five distinct families of RNA viruses: the families Filoviridae, Flaviviridae, Rhabdoviridae, and several member families of the Bunyavirales order such as Arenaviridae, and Hantaviridae. According to the Pan American Health Organization (PAHO), the clinical description of dengue fever is an acute febrile illness of 2-7 … Dengue hemorrhagic fever is caused by a bite of a vector mosquito called, Aedes Aegypti. Pathophysiology Dengue hemorrhagic fever is a severe, potentially deadly infection spread by some mosquitos. Pathophysiology The diversity of clinical features seen among the VHF infections probably originates from varying mechanisms of pathogenesis. Dengue hemorrhagic fever is a more severe form of a … Dengue hemorrhagic fever can occur when someone is bitten by a mosquito or exposed to blood infected with the dengue virus. Confirmed Dengue Fever!-4 -2 02 46 81 01 2 Febrile Phase Critical Phase Recovery Phase Viremia NS1a ntigen Mosquito bite IgG IgM Fever Shock Bleeding days A B FIGURE 1. The most common fever pathophysiology, however, is due to infection with invading organisms such as viruses and bacteria. I. If the address matches an existing account you will receive an email with instructions to reset your password Immunological enhancement and the pathogenesis of dengue haemorrhagic fever BY J. S. PORTERFIELD Sir William Dunn School of Pathology, South Road, Parks Oxford OX\ 3RE {Received as part of an academic tribute to A. W. Doumie) SUMMARY Laboratory studies have provided evidence that the replication of Description. The most widely-cited hypothesis for the pathogenesis of severe dengue is antibody-dependent enhancement (ADE).. an acute febrile disease caused by infection with one of the serotypes of the dengue virus. The most widely -cited hypothesis for this occurrence is antibody -dependent enhancement (ADE) of Thein TL, Wong J, Leo YS, et al. Dengue viruses belong to the family Flaviviridae and the four recognized serotypes (dengue-1, dengue-2, dengue-3, dengue-4) cause a spectrum of disease ranging from an undif-ferentiated febrile illness to the severe, life-threatening dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). 11, November 2009. human is the source of infection for an adult mosquito, which Dengue hemorrhagic fever (DHF): A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage (bleeding) and circulatory collapse ().DHF starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. PATHOPHYSIOLOGY. • Dengue-like illness: illness defined by fever as reported by the patient or healthcare provider. Furthermore, when infected for a second time with a different serotype, a more severe infection may occur. Clinical Features of Dengue Infection 11-14 6. This video aims to describe the mode of replication of Dengue virus and the pathophysiology of dengue infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Fever pathophysiology, therefore, is the rise in the body's temperature due to the changes caused by a disease. Browse more videos. Hemorrhagic complications range from simple petechiae and purpura to gastrointestinal bleeding, hematuria, and severe central nervous system (CNS) bleeds. Classical dengue fever is observed more frequently in adults and occurs after an incubation of 4–7 days , . dengue fever; however, as the fever declines, symptoms quickly progress to include frequent vomiting, severe stomach pain, difficulty breathing and significant bleeding. As the death toll is rising day by day yet, the city corporation is taking not enough precautions lately. pdf, 58kb; Chapter 7. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Medical Diagnosis. •The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue. Daily dengue haemorrhagic fever record sheet pdf, 27kb; Annex 3. Yacoub S, Lam PK, Huynh TT, et al. Dengue fever is the most common &important arthropod borne viral disease in human. Early diagnosis of dengue fever contributes towards better management of the disease and its complications. These altered ultrastructures serve as sites for viral replication. Dengue fever is now the talk of the country. Fever is the elevation of the body's temperature above the normal level. Clinically, the manifestations of DENV infection can range from mild-acute undifferentiated febrile illness to classical dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) according to WHO 1997 dengue guideline 1 ().DF is an acute febrile illness that presents symptoms such as bone or joint and muscular pains, headaches, leukopenia and rash. Title: Studies on the pathophysiology of dengue haemorrhagic fever and dengue shock syndrome: Author(s): Gorp, E.C.M. Pathogenesis of dengue fever pdf Discover the full Audi range to find the perfect car for you We use cookies to support your experience on our website, including to personalise content, to provide social media features and to analyse traffic. Pathophysiology of dengue fever: Dengue infection is caused by bites of the female Aedes aegypti mosquito carrying Flavivirus. Dengue infection is caused by 4 antigenically distinct dengue virus serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. The clinical manifestations of children with DEN can differ from adults – cough, vomiting and abdominal pain appear to be more common . •Common name of the disease is ‘break-bone fever’ (Haddi Tod Bukhar (hDI taoD bauKar) After a person is bitten, the virus incubation period varies between 3 and 14 days, after which the person may experience early symptoms such as fever… Dengue infection is caused by 4 antigenically distinct dengue virus serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy, 2000. Clin Infect Dis 2017; 65:1453. ISBN: 978-1-908978-79-0 (ebook) USD 84.00. A, Revised dengue fever case 1classification,adapted from World Health Organization 2009. •Dengue is a mosquito-borne, viral infection. pathophysiology of dengue hemorrhagic fever.wmv. ISBN: 978-1-908978-79-0 (ebook) Checkout. An estimated 2.5 billion people are at risk of dengue infection, and of the 100 million cases of dengue fever per year, up to 500,000 develop dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), the life-threatening forms of the infection. Transmission occurs through the bite of infected Aedes mosquitoes, principally Aedes aegypti, which is also the principal urban vector of yellow fever. The preventive measures should include the use of mosquito nets to prevent dengue fever from being bitten by mosquitoes and these may spread the disease to others. Recent advances in electron microscopy and tomography have revealed distinct virus-induced endoplasmic reticulum (ER) structures unique for dengue virus (DV) and other flaviviruses in cell culture models, including hepatocytes. Four prospective studies have been carried out across the dengue belt, many groups have been pushing at the question of pathogenesis of dengue haemorrhagic fever, Dengue fever is characterised by temperature that is usually high up to 104° F to 106° F, associated with severe joint pains, headache as well as skin rash. Symptoms of Dengue hemorrhagic fever are fever that lasts from 2 to 7 days, Vomiting blood, Drowsiness, Bleeding from nose or gums. Fever may be mild or high, presenting abruptly with photophobia, headache, and retro-orbital pain in addition to the other features of dengue. Classical dengue fever: It is characterized by fever, rashes, severe headache, pain behind eyes, pain in muscle and joints, enlarged lymph nodes, Fever lasts for 2-7 days; Myalgia and break bone fever ( deep bone pain) is the characteristic of Dengue fever; Classical dengue fever is self-limited. Infected mosquitoes are the most common causes. Typhoid Fever Pathophysiology amp; Schematic Diagram - These days we want to discuss the article with the title health Typhoid Fever Pathophysiology amp; Schematic Diagram we hope you get what you're looking for. Although the exact mechanisms are not clear, ADE is the process in which DENV, complexed with nonneutralizing antibodies, can enter a greater … This mosquito is considered to be a day- biting and low flying mosquito and commonly be found inside the household. Download Free PDF. Dengue (DENG-gey) fever is a mosquito-borne illness that occurs in tropical and subtropical areas of the world. They are RNA viruses that belong to the Flavivirus genus/Flaviviridae family, which also includes the yellow fever virus, West Nile virus, Japanese encephalitis virus, Zika virus, and the St Louis encephalitis virus. Download Free PDF. PATHOPHYSIOLOGY-OF-DENGUE-FEVER.pdf - PATHOPHYSIOLOGY OF DENGUE FEVER PREDISPOSING FACTORS Geographical areatropical\/subtropical Ages 15 years below Severe dengue most commonly occurs among infants and patients with secondary dengue virus (DENV) infections (i.e., infection with a DENV type different from what they were previously infected with earlier in life). Infection occurs when one of four dengue virus serotypes (DENV 1–4) are transmitted to humans by Aedes sp. Pathophysiology of Dengue Haemorrhagic Fever 7 4. Dengue and dengue hemorrhagic fever (DHF) result from infection by any of four serotypes of dengue viruses. Association Between Increased Vascular Nitric Oxide Bioavailability and Progression to Dengue Hemorrhagic Fever in Adults. Characteristic findings in dengue fever : • Thrombocytopenia (platelet count < 100 x 109/L) • Leukopenia • Mild to moderate elevation of aspartate aminotransferase and alanine aminotransferase values In patients with dengue hemorrhagic fever: • Increased hematocrit level secondary to plasma extravasation and/or third-space fluid loss • Hypoproteinemia • Prolonged prothrombin time • … med dengue fever (DF) to the most severe forms, den-gue hemorrhagic fever and dengue shock syndrome (DHF/DSS). Recovery generally takes two to seven days. A global strategy on dengue fever and DHF was developed in 1995 and its implementation These viruses are related to the viruses that cause the West Nile infection and yellow fever. (primarily Aedes aegypti) mosqui-toes [1]. [] Secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for the development of DHF. While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. 2. The dengue virus is an arbovirus transmitted by Aedes mosquitoes. Know the causes, symptoms, pathophysiology, treatment, prognosis, survival rate and home remedies for dengue fever using … 1. Report. DHF/DSS pathophysiology is not entirely unders-tood. Pathophysiology Dengue Hemorrhagic Fever Virus Veterinary Medicine For more information and source, see on this link : https://www.scribd.com/doc/27445781/Pathophysiology-Dengue-hemorrhagic-fever Factors Associated With Dengue Shock Syndrome A Systematic Review And Meta Analysis Hospital flow chart pdf, 68kb; Annex 5. Dengue may be caused by any of the dengue viral serotypes. Clinical Course of Dengue Haemorrhagic Fever 15 7. The first recorded epidemic of dengue was reported in the late 18th century and affected Asia, Africa, and North America. Female mosquitoes, predominantly of the species Aedes aegypti and less commonly, Aedes albopictus, The initial case in the Florida Keys was found in … For more information please read our cookie policy. The WHO estimates that 50-100 million cases of dengue infection occur annually, with approximately 500,000 of those cases resulting in dengue hemorrhagic fever (DHF), with an estimated 22,000 deaths per year, mostly in children. A viraemic 876 Reprinted from AusTRAlIAn FAMIly PHysIcIAn Vol. For more information and source, see on this link : https://www.slideshare.net/fareedresidency/dengue-fever-pharmacy-presentation During dengue virus infection a unique cytokine, cytotoxic factor (hCF), is produced that is pathogenesis-related and plays a key role in the development of dengue haemorrhagic fever (DHF). The first stage is the fusion, which is mediated by the viral envelope (E) glycoprotein which is important for infectivity. Sayid Ridho. The pathology of dengue hemorrhagic fever. An immunopathogenic mechanism, for example, has been identified for dengue hemorrhagic fever , which usually occurs among patients previously infected with a heterologous dengue serotype. PATHOGENESIS OF DENGUE FEVER/DHF. Definition. Symptoms of dengue fever: In case of severe pain or fever you can take paracetamol. Dengue is the most common and important mosquito-borne viral infection and can manifest as Dengue Fever (DF), which is often a self-limiting febrile illness or less commonly dengue hemorrhagic fever (DHF). Sensors Free Full Text A Sensitive And Selective Label Free Electrochemical Dna Biosensor For The Detection Of Specific Dengue Virus Serotype 3 Sequences The most important pathophysiological event in DHF/DSS is plasma leakage that causes pleu-ral effusion, ascites and occasionally death [1, 2]. PATHOPHYSIOLOGY-OF-DENGUE-FEVER.pdf - PATHOPHYSIOLOGY OF DENGUE FEVER PREDISPOSING FACTORS Geographical areatropical\/subtropical Ages 15 years below There are many causes of fever. Definition of Dengue Fevers (WHO 1997) 8-10 5. Dengue Virus

• Causes dengue and dengue hemorrhagic fever

• Is an arbovirus

• Transmitted by mosquitoes

• Composed of single-stranded RNA

• Has 4 serotypes (DEN-1, 2, 3, … Symptoms typically begin three to fourteen days after infection. Dengue fever is a disease caused by a family of viruses transmitted by mosquitoes. AETIOLOGY,PATHOPHYSIOLOGY AND DIAGNOSIS OF DENGUE INFECTION DR LEE OI WAH PEG. Download Dengue guideline 2018 for sigh symptoms, investigations and treatment of dengue. The clinical manifestations range from asymptomatic infection to undifferentiated fever, dengue fever and dengue hemorrhagic fever (DHF). DHF is characterized by sustained high fever for 2–7 days; bleeding diathesis such as positive tourniquet test, petechiae, epistaxis and hematemesis; thrombocytopenia with platelet counts ≤ 100 × 10 9 /L and plasma leakage due to increased vascular permeability evidenced by hemoconcentration, pleural effusion and ascites. By clicking accept you agree to our use of cookies. Download PDF. Outpatient flow chart pdf, 51kb; Annex 4. The disease can also be transmitted via both blood transfusion and transplacentally during pregnancy. Generally, infection with one serotype confers future protective immunity against that particular serotype but not against other serotypes. World Health Organization, Regional Office for South-East Asia. Epidemiology of Dengue Fever in Malaysia 3-4 2. Dengue fever is a mosquito-borne viral disease caused by 1 of 4 closely related but antigenically distinct serotypes of dengue virus, serotypes DENV-1 … Insights into the pathogenesis of severe dengue ... ther dengue fever or dengue hemorrhagic fever, with the latter classified as grade 1, 2, 3, or 4. Supplementary. Dengue is the most common and important mosquito-borne viral infection and can manifest as Dengue Fever (DF), which is often a self-limiting febrile illness or less commonly dengue hemorrhagic fever (DHF).

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